Biochem/physiol Actions

Reversible: yes

Primary TargetFtsZ

Cell permeable: yes

General description

A benzamide ether derivative that exhibits potent bactericidal activity against Staphylococcus aureus and Bacillus subtilis (minimum inhibitory concentration = 0.5 to 1 µg/ml), but does not affect E. coli, yeast, or human hepatocytes. Shown to reduce GTPase activity and induce FtsZ (a prokaryotic homologue of tubulin) polymerization in S. aureus in a dose-dependent manner. Reported to directly inhibit the GTPase activity of FtsZ in a concentration dependent manner (IC₅₀ = 55 ng/ml). Shown to bind between the C-ternimal domain and helix 7 in a region analogous to the Taxol binding site of tubulin. Increases the survival rate to 100% in mice subjected to a lethal dose of S. aureus.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Elsen, N. L., et al. 2012. J. Am. Chem. Soc.134, 12342.Andreu, J. M., et al. 2010. J. Biol. Chem.285, 14239.Haydon, D. J., et al. 2008. Science, 321, 1673.Sorto, N. A., et al. 2010. J. Org. Chem.75, 7946.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)